Posts - Validation

Nov 8, 2021 11:36am
From Hillary Thurman: Here is some additional information, in response to Bob Gosselin's 11-6-21 response:
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Nov 6, 2021 6:29pm
Hillary Thurman is looking for some insight, She writes, "We have recently standardized hemostasis instruments across our system. The rest of the system has been using a combined geometric mean for their PT reagent (same lot, same instruments), but my site has never been involved in this. In addition, they do not change the geomean between reagent lots unless the new lot geomean is more than +/- 0.3 from the current lot."
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Oct 24, 2021 7:29pm
In Keohane EM, Otto CN, Walenga JM: Rodak's Hematology; Clinical Principles and Applications, Sixth Edition, 2020, Dr.
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Oct 23, 2020 12:44pm
Mike Meyer asks, "we run three dilutions for all of our factor testing. Occasionally, we see results in which upon higher dilutions, the factor value decreases after adjusting for the dilution. For instance, I had a case today in which the FIX values were 0.64, 0.55, and 0.43 U/mL for the 1:10, 1:20, and 1:40 dilutions [values corrected for the dilution effect], the opposite effect seen with inhibitors. Calibration curve seems fine." He adds, "the patient’s FVIII level was very high [about 3.60 U/mL]. We possibly thought that the higher dilutions would bring the FVIII level back closer to a more normal range. The high concentration of FVIII in the first dilution may be accelerating the PTT clotting time yielding a falsely higher FIX value. Please comment."
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