Quick Question: Factor VIII Assay

Quick Question: Factor VIII Assay
Jul 4, 2018 12:41pm

Here are the unsprprising resuts of our June, 2018 Quick Question, "How do you measure factor VIII therapy?"

  1. Clot-based factor assay: 82% (36)
  2. Immunoassay: 5% (2)
  3. Chromogenic substrate: 14% (6)

Dave McGlasson suggested this question because our current clot-based methods are unreliable when assaying for synthetic B-domain deleted and extended half-life preparations, many of which are also B-domain deleted. Our clot-based assays, which have always suffered from imprecision, are relatively inaccurate when measuring the newer synthetic concentrates. A number of rresearchers are now developing new, more accurate measures that we will be reporting on as they are developed.

0 Comments

Here are the unsprprising resuts of our June, 2018 Quick Question, "How do you measure factor VIII therapy?"

  1. Clot-based factor assay: 82% (36)
  2. Immunoassay: 5% (2)
  3. Chromogenic substrate: 14% (6)

Dave McGlasson suggested this question because our current clot-based methods are unreliable when assaying for synthetic B-domain deleted and extended half-life preparations, many of which are also B-domain deleted. Our clot-based assays, which have always suffered from imprecision, are relatively inaccurate when measuring the newer synthetic concentrates. A number of rresearchers are now developing new, more accurate measures that we will be reporting on as they are developed.

Leave A Comment

You must be logged in to Comment - Sign In