Quick Question: DRVVT Results

Quick Question: DRVVT Results
Oct 2, 2018 6:31am

The International Society on Thrombosis and Haemostasis and the Clinical and Laboratory Standards Institute agree that the lupus anticoagulant (LAC ) test profile should employ two testing platforms, and both recommend, among other choices, an assay based upon the dilute Russell viper venom time (DRVVT ) and a second assay based on the PTT.

Each platform employs a low phospholipid reagent sensitive to LAC as the first-tier or "screen" stage and a second, high phospholipid "confirm" reagent. Some experts advocate for normalization in which the two results for each platform are normalized to the MRI in this formula: Normalized ratio = (screen result/MRI) / (confirm result/MRI). Others prefer the simpler formula, Ratio = screen results/confirm results, and still others prefer s simple difference in seconds. Our October, 2018 Quick Question polls our participants on these preferences. Which formula does your laboratory apply for the DRVVT ?
 

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The International Society on Thrombosis and Haemostasis and the Clinical and Laboratory Standards Institute agree that the lupus anticoagulant (LAC ) test profile should employ two testing platforms, and both recommend, among other choices, an assay based upon the dilute Russell viper venom time (DRVVT ) and a second assay based on the PTT.

Each platform employs a low phospholipid reagent sensitive to LAC as the first-tier or "screen" stage and a second, high phospholipid "confirm" reagent. Some experts advocate for normalization in which the two results for each platform are normalized to the MRI in this formula: Normalized ratio = (screen result/MRI) / (confirm result/MRI). Others prefer the simpler formula, Ratio = screen results/confirm results, and still others prefer s simple difference in seconds. Our October, 2018 Quick Question polls our participants on these preferences. Which formula does your laboratory apply for the DRVVT ?
 

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