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About

Welcome and thank you for your interest in The Fritsma Factor!

This forum has been designed as a common place for us to access and share knowledge, information and insight about the world of hemostasis. The idea and motivation for this resource came from numerous discussions I’ve been having with my peers over the years. Although conferences provide a good forum to share new (and old) information, the common theme that echoed through all of my discussions was the desire to have a more widely accessible educational forum that allows for ongoing knowledge discovery and dissemination. So I thought, let’s go virtual!

Please know that this really is a living, breathing space and, with your help, we have become a “blogging” community. I encourage you to participate in its growth and share your feedback for improvements so that I can review them and implement when and wherever possible.

Enjoy your stay and please come back to visit!

1 Comment

  • By HCROWN280ZX, June 2, 2010 @ 12:13 pm

    Hello George, I just completed the Quick Question concerning aPTT mixing studies. Our aPTT mixing study consists of two parts, a control of NPP and Factor VIII deficient plasma tested immediately upon preparation and after 60 minutes incubation at 37 degrees. The patient is also mixed 50/50 with NPP and tested immediately upon preparation and after 60 minutes incubation.

    We established a normal reference range for these studies by testing a group of normal donors from our lab and surrounding offices. All donors were Lupus Anticoagulant Negative by Sta-Clot LA, DRVVT and Dilute PT index. All donors had normal PT, aPTT and Thrombin Times.

    We always perform these mixing studies at “zero time” and after 60 minutes. Without the additional incubation step, a physician would be unable to determine the presence of a factor inhibitor.

    Regards
    Herb Crown
    St. Louis University Hospital Coagulation Laboratory

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