On June 12, Kim Kinney asked about applying the 2009 ISTH Lupus Anticoagulant Testing Guidelines. The Precision Biologic, Inc scientific staff have prepared a concise summary of the guidelines available on www.PrecisionBiologic.com. Click here for the summary. Geo.
Mixing Studies | GeorgeFritsma | 
June 27, 2010 12:12 pm | 
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Here are the results of our June QQ on Mixing Studies:
When performing a partial thromboplastin time (PTT) mixing study using reagent pooled normal plasma (PNP), what do you use as your correction/non-correction limit?
a. Mixture PTT is within 10% of the PNP PTT result: 9 (14%)
b. Mixture PTT is within 5 seconds of the PNP PTT result: 12 (19%)
c. Mixture PTT is within the PTT reference interval: 34 (53%)
d. Rosner index: 6 (9%)
a. Other: 3 (5%)
Mixing Studies, Quick Question Archive | GeorgeFritsma | 3:47 am | Comments (0)
I have this message from Theresa Nwagha, University of Nigeria Nsukka:
I am performing a functional assay of protein C in pregnancy will need help with SOP. Not a routinely performed assay in my center.
Method Validation | GeorgeFritsma | 3:23 am | Comments (0)
From D. Kaguni:
I would like to know where I would find information on validation of a rare factor activity assay in which the test kit is quite expensive and performing the recommended 120 normal plasmas to create a reference range would be very expensive. I have inquired with CLSI and they do not have definitive guidelines concerning a situation like this. Thank you for your assistance.
Method Validation | GeorgeFritsma | June 18, 2010 9:17 am | Comments (0)
Margaret Peters, MD at MHS Health asks:
What coagulation tests may be run on samples previously treated with heparinase? Is any correction factor required for a quantitative assay? Are there any published guidelines on this topic? Thank you!
Specimen Collection | GeorgeFritsma | June 15, 2010 4:05 pm | Comments (0)
Joe Lamb asked, “George, I’m working on mixing study procedures for my lab. I’ve read about a saline mix and I’m looking for a reference for the technique. I’m interested in a procedure and how to interpret the results. can you recommend something for me?”
Mixing Studies | GeorgeFritsma | 3:20 pm | Comments (5)
From Greg Fullerton at Affinity Biologicals, Inc.
Hi George,
I am new to the industry and enjoy reading your site. It gives me a lot of insight into the world of hemostasis. I have two coagulation market related questions for you and a top five list. Hope you can help me out.
1) In your estimation, what would the volume of coagulation test be for the North American market in a year?
2) What percentage of people actually use frozen reagents compared to lyophilized? I know the preference is frozen, but actual use is different I’m sure.
3) What would your top 5 “reads” be for a student new to the field of hemostasis?
Take care and keep up the good work.
Greg Fullerton
Manager, Sales & Marketing
Affinity Biologicals Inc.
General | GeorgeFritsma | June 12, 2010 5:28 am | Comments (1)
From Kim Kinney at Clarian Health in Indianapolis:
Hi George. It was good to see you at the Midwest Hemostasis Symposium this year. My question stems from one of the presentations. There was a presenter from Texas, I believe, who gave a talk on multiple miscarriages. He mentioned that he had been at the recent ISTH meeting and referred to the updated guidelines. Our pathologist is going to try to convince a group of docs here at Clarian that IgA testing is not first-line testing for APA antibodies. Our pathologist is interested in talking with other docs before he presents to our group. Do you know the presenter’s contact information? Could you also refer me to the current guidelines? Thanks for the help, as always.
Mixing Studies, Thrombophilia Testing | GeorgeFritsma | 4:46 am | Comments (0)
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