Another interesting discussion from our UMDNJ graduate Hemostasis course:
About 6 years back, I caught wind of a discussion regarding platelet substitutes, which I found quite intriguing. I did some digging as a result of this discussion and am amazed by the potential of such technologies. It appears that platelet rich plasma (PRP) gel has been around for some time, more than two decades according to Carter, et al. (2011). Do you know how often and in what circumstances such a technology as PRP gel is utilized?
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Here is another cogent comment from a University of Medicine and Dentistry Graduate Student. I didn’t get permission to post the student’s name, will add it later in a comment if permission is granted. We got into a side “conversation” about inflammatory markers and their crosstalk with hemostasis. As you can see, we get into some high-level discussions in this graduate course. Geo.
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I’m having some fun this week teaching a unit in the online graduate hemostasis course at the University of Medicine and Dentistry of New Jersey at the invitation of Drs Elaine Keohane and Nadine Fydryszewski. This also gives me the opportunity to work with colleagues Donna Castellone and Dr. Larry Smith. Many of our twelve students are seasoned veterans in hematology and coagulation laboratories. Here is a comment about PT/PTT screens from graduate student and lab manager Steve Marionneaux:
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Hi George! Would you happen to have a list of laboratories performing the anti-Xa assay for Fondaparinux (pentasaccharide, Arixtra)? Do you recommend, when calibrating the assay, to use commercially-available material or spiked normal pooled plasma (NPP)? Thanks for your help!! Love this resource that you provide!!
Crystal Azevedo, MT(ASCP)SH
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Coming up in just two weeks is the Greater New Orleans Coagulation Conference, February 9–10, 2012 at the New Orleans Marriott in Metarie, LA. Precision BioLogic, Inc will be exhibiting at the conference, and we look forward to seeing you there. Also, please visit our recently updated list of 2012 Coagulation Conferences.
If you know of a coagulation or general-topics conference that does not appear on the list, please send me the information and I will gladly post it. Geo.
From “rhe25″:
Hi, George, glad to find your resourceful website! Question for you: when the D-dimer is very very high, but the soluble fibrin monomer complex (SFMC) is negative, does that mean primary fibrinolysis in a systemic amyloidosis patient who has bleeding? I have seen a case like this, but the fibrinogen level is elevated, going against primary fibrinolysis. Doesn’t look like overt DIC clinically. Could the very high D-dimer be a lab artifact? Thanks!
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Laura Lum, Seattle Children’s Hospital, asks, What is the ristocetin cofactor assay for, how is it performed, and can it be done on an STA Compact?
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From Heidi Lawson:
I was wondering if you had any information on why multiple myeloma (MM) patient specimens do not (at times or at all) spin down well in serum separator tubes (SST) or red top tubes. I called BD and they gave me a small excerpt of information stating that MM patients, due to myeloma proteins, inhibit the three stages of fibrin formation. Do you have any additional information that may be useful in understanding this phenomenon a little better? Thanks!
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Aspirin and Platelets, Bleeding Disorders | GeorgeFritsma | 
February 1, 2012 5:47 am | 
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