From Nancy Fabbrini: We have a patient on an argatroban bridge to warfarin. He is a very difficult draw so the service has been drawing blood from the central access device. They have been withdrawing 20 mL of blood before drawing the tube for coagulation testing. Is that sufficient, i.e. do the same “rules” for a line with heparin apply to argatroban? Thank you.
George, I noticed on Fritsma Factor the question on using Kcentra to reverse DOACs. I just got this off Medscape on a phase 3 study of an antidote to the factor Xa inhibitor apixaban. An IV bolus of andexanet alfa immediately and significantly reversed apixaban in 33 healthy volunteers enrolled in the ANNEXA-A study. The authors also state that Idarucizumab reverses the oral thrombin inhibitor dabagatran etexilate mesylate. Both have FDA breakthrough status.
David L. McGlasson, GS-13
Clinical Research Scientist
From Gabor Varadi, Einstein Healthcare:
Hello George, I would like to ask your opinion about using 4-component prothrombin complex concentrate (PCC) for rivaroxaban and dabigatran-induced life-threatening bleeding. Any scientific data to support using this product? Thank you.
From Scott Miller at St. Mary’s of Michigan: Just a note. We use both the PFA-100 and the Verify Now for platelet function testing. I am unable to get the poll to accept more than one response. Scott
Thank you, Scott, we will add your response to the total when we publish the results. Geo
We have two valuable posts on the December 3, 2013 topic of Thromboelastograph (TEG) versus the Rotational Thromboelastometer (ROTEM), asking about transporting platelet function testing specimens through the tube system. I just want to ensure you didn’t miss this useful information.