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Comments for Fitzgerald and Fletcher Factor Deficiencies

Hi, Boaz

Boaz, it is good to hear from you, I remember you fondly as a Fogarty Scholar and graduate student in Clinical Laboratory Sciences at the University of Alabama at Birmingham. I hope you are doing well back home in Uganda, wish you well, and invite you to contribute your information and questions to Fritsma Factor! Geo

posted by GeorgeFritsma at Saturday, May-23-2009 17:57pm

Hi George

Greeting from Uganda. I have come across this site that seem to be yours. It is very interesting, informative and educative to many. Lots of thanks to you for this wonderful inovation. Thank you for the professional contribution you're making to the entire world. I salute you! Moaz Iga MS,MT(ASCP)

posted by boaziga at Friday, May-22-2009 01:21am

Followup on Fletcher and Fitzgerald Deficiency

Kim, though the combination seems almost infinitely rare, the Colman text does describe a few cases of combined deficiency and also reports experiments linking both PK and MHWK to tissue plasminogen activator (TPA) and urokinase activation subsequent to endothelial cell binding. Thus, though rare, it definitely is a possibility, especially if there is not other explanation. Colman does state the association is experimental and requires more definitive clinical data. Thank you for your response. Geo.

posted by GeorgeFritsma at Saturday, May-16-2009 15:51pm

Untitled

Thanks George. This patient actually did have a dRVVT and it was normal. Also, her mixing study showed very strong correction and none of her PTT factors showed any dilutional effect. I did finally find a blurb in a Coleman reference that there may be some association with thromboembolic disease and that both index cases for PK and HMWK dificiency had DVT/PE. Thanks again.

posted by kjkinney at Tuesday, May-05-2009 09:27am