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Cell-based CoagulationA new approach to the coagulation mechanism
What is thromboplastin?> Friday, March-14-2008Dear George, This is back to basics but, believe it or not, some of us are coming up with different ideas of what exactly "thromboplastin" is and exactly which cells it is normally a part of. Could you please define it for us and clear up the confusion? Thank You, Anne Dagostino How Do Factor VIII or IX Deficiency Cause Bleeding?> Friday, February-29-2008
Hi George,
Thank you, thank you, thank You for your educational materials. I have been a tech for 20-some years but this is my first year in special coag and your lectures have helped me tremendously. From the cell-based coagulation lectures, I am having trouble understanding why the TF/VIIa route does not compensate for a lack of IX or VIII. I understand that the Xa is "on the wrong cell" but after injury to the vessel and exposure of the cell to the platelet, why doesn't the direct hand-off of Xa and the small amount of thrombin that gets "directly handed to the platelet" create amplification through that part of the "new extrinsic pathway?" Is it simply that there is not enough of the Xa/Va complex generated to cause the formation of enough thrombin to create enough fibrin? Or does it not get handed off to the platelet after exposure because there is no IXa? Please clear away the fog! Thank you, Anne From: avbdaggy@yahoo.com Seminars in Wyoming and Maine> Monday, September-17-2007What do you think about the new cell-based coagulation...
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